A31 MECHANISMS IN CYSTIC FIBROSIS AND OTHER BRONCHIECTATIC DISEASES: Alpha-1 Antitrypsin Is Less Effective At Inhibiting Neutrophil Elastase Activity And Cxcr1 Cleavage In Cystic Fibrosis Versus Non-Cf Bronchiectasis Respiratory Secretions Due To The Actions Of Other Serine And Non-Serine Proteases
Introduction: The major target in treating the proteolytic burden in cystic fibrosis (CF) and non-CF bronchiectasis (NCFB) is neutrophil elastase (NE), which is inhibited by alpha-1 antitrypsin (AAT). Conclusion/Discussion: The clinical implication of these results is that anti-NE therapy alone may...
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Published in | American journal of respiratory and critical care medicine Vol. 195 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
American Thoracic Society
01.01.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Introduction: The major target in treating the proteolytic burden in cystic fibrosis (CF) and non-CF bronchiectasis (NCFB) is neutrophil elastase (NE), which is inhibited by alpha-1 antitrypsin (AAT). Conclusion/Discussion: The clinical implication of these results is that anti-NE therapy alone may be insufficient to address the protease burden in the CF lung, and may require combination with other protease inhibitors. |
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ISSN: | 1073-449X 1535-4970 |