D97 IMPACT OF INFLAMMATION ON ACUTE LUNG INJURY: Being A Good Influence? Alveolar Type 2 Cells Dampen Macrophage Inflammatory Response In Acute Lung Injury Via Glycolysis Driven Mechanism
Introduction Loss of type II airway epithelial cells (ATII) is a key pathologic feature of acute lung injury (ALI), a clinical syndrome responsible for high mortality and significant morbidity. Shifting glucose metabolism away from glycolysis either with a chemical inhibitor or with genetic knock do...
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| Published in | American journal of respiratory and critical care medicine Vol. 195 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
American Thoracic Society
01.01.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Introduction Loss of type II airway epithelial cells (ATII) is a key pathologic feature of acute lung injury (ALI), a clinical syndrome responsible for high mortality and significant morbidity. Shifting glucose metabolism away from glycolysis either with a chemical inhibitor or with genetic knock down altered the ability of epithelial cells to inhibit macrophage responsiveness to LPS. |
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| AbstractList | Introduction Loss of type II airway epithelial cells (ATII) is a key pathologic feature of acute lung injury (ALI), a clinical syndrome responsible for high mortality and significant morbidity. Shifting glucose metabolism away from glycolysis either with a chemical inhibitor or with genetic knock down altered the ability of epithelial cells to inhibit macrophage responsiveness to LPS. |
| Author | Roy, R Stenmark, K R Burns, N Vohwinkel, C El Kasmi, K C Eltzschig, H |
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| Snippet | Introduction Loss of type II airway epithelial cells (ATII) is a key pathologic feature of acute lung injury (ALI), a clinical syndrome responsible for high... |
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| Title | D97 IMPACT OF INFLAMMATION ON ACUTE LUNG INJURY: Being A Good Influence? Alveolar Type 2 Cells Dampen Macrophage Inflammatory Response In Acute Lung Injury Via Glycolysis Driven Mechanism |
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