C31 BASIC AND TRANSLATIONAL STUDIES ON THE ROLE OF THE EPITHELIUM: The Neurotrophin 4 - Pulmonary Neuroendocrine Cell Axis In Early Life Allergen-Induced Mucus Overproduction
Here we show that neurotrophin 4 (NT4) orchestrates PNEC innervation and secretion of Y-aminobutyric acid (GABA) for allergen-induced mucus overproduction in early life. Targeting NT4 function along the nerve-PNEC axis may be a valid treatment strategy for mucus overproduction in airway diseases, su...
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| Published in | American journal of respiratory and critical care medicine Vol. 195 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
American Thoracic Society
01.01.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Here we show that neurotrophin 4 (NT4) orchestrates PNEC innervation and secretion of Y-aminobutyric acid (GABA) for allergen-induced mucus overproduction in early life. Targeting NT4 function along the nerve-PNEC axis may be a valid treatment strategy for mucus overproduction in airway diseases, such as childhood asthma. |
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| AbstractList | Here we show that neurotrophin 4 (NT4) orchestrates PNEC innervation and secretion of Y-aminobutyric acid (GABA) for allergen-induced mucus overproduction in early life. Targeting NT4 function along the nerve-PNEC axis may be a valid treatment strategy for mucus overproduction in airway diseases, such as childhood asthma. |
| Author | Achey, R Randell, S H Miller, L A Ai, X Aven, L Park, J-A Barrios, J |
| Author_xml | – sequence: 1 givenname: X surname: Ai fullname: Ai, X – sequence: 2 givenname: J surname: Barrios fullname: Barrios, J – sequence: 3 givenname: L surname: Aven fullname: Aven, L – sequence: 4 givenname: R surname: Achey fullname: Achey, R – sequence: 5 givenname: S surname: Randell middlename: H fullname: Randell, S H – sequence: 6 givenname: J-A surname: Park fullname: Park, J-A – sequence: 7 givenname: L surname: Miller middlename: A fullname: Miller, L A |
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| Snippet | Here we show that neurotrophin 4 (NT4) orchestrates PNEC innervation and secretion of Y-aminobutyric acid (GABA) for allergen-induced mucus overproduction in... |
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| Title | C31 BASIC AND TRANSLATIONAL STUDIES ON THE ROLE OF THE EPITHELIUM: The Neurotrophin 4 - Pulmonary Neuroendocrine Cell Axis In Early Life Allergen-Induced Mucus Overproduction |
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