C31 BASIC AND TRANSLATIONAL STUDIES ON THE ROLE OF THE EPITHELIUM: The Neurotrophin 4 - Pulmonary Neuroendocrine Cell Axis In Early Life Allergen-Induced Mucus Overproduction

Here we show that neurotrophin 4 (NT4) orchestrates PNEC innervation and secretion of Y-aminobutyric acid (GABA) for allergen-induced mucus overproduction in early life. Targeting NT4 function along the nerve-PNEC axis may be a valid treatment strategy for mucus overproduction in airway diseases, su...

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Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Ai, X, Barrios, J, Aven, L, Achey, R, Randell, S H, Park, J-A, Miller, L A
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
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Summary:Here we show that neurotrophin 4 (NT4) orchestrates PNEC innervation and secretion of Y-aminobutyric acid (GABA) for allergen-induced mucus overproduction in early life. Targeting NT4 function along the nerve-PNEC axis may be a valid treatment strategy for mucus overproduction in airway diseases, such as childhood asthma.
ISSN:1073-449X
1535-4970