C21 OMICS IN LUNG DISEASE: Human Small Airway-On-A-Chip: A Novel Microphysiological System To Model Lung Inflammation, Accelerate Drug Development And Enable Inhalational Toxico-Analysis

Importantly, by connecting the small airway chip to a custom-designed electromechanical instrument that 'breathes' whole cigarette smoke in and out of the chip microchannels, we successfully recreated smoke-induced oxidative stress, identified new ciliary micropathologies, and discovered u...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 195
Main Authors Benam, K, Novak, R, Villenave, R, Lucchesi, C, Hubeau, C, Nawroth, J, Hirano-Kobayashi, M, Ferrante, T C, Choe, Y, Prantil-Baun, R, Weaver, J C, Hamilton, G A, Bahinski, A, Parker, K K, Ingber, D E
Format Journal Article
LanguageEnglish
Published New York American Thoracic Society 01.01.2017
Subjects
Chronic obstructive pulmonary disease
Cytokines
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Summary:Importantly, by connecting the small airway chip to a custom-designed electromechanical instrument that 'breathes' whole cigarette smoke in and out of the chip microchannels, we successfully recreated smoke-induced oxidative stress, identified new ciliary micropathologies, and discovered unique COPD-specific molecular signatures. [...]this platform revealed a subtle ciliary damage triggered by acute exposure to electronic cigarette. [...]the human small airway-on-a-chip offers a powerful complement to animal models for studying human lung pathophysiology.
ISSN:1073-449X
1535-4970