Molecular mechanism of G[alpha]i activation by non-GPCR proteins with a G[alpha]-Binding and Activating motif

• Published in: Nature communications Vol. 8; p. 15163
• Main Authors: De Opakua, Alain Ibáñez, Parag-sharma, Kshitij, Digiacomo, Vincent, Merino, Nekane, Leyme, Anthony, Marivin, Arthur, Villate, Maider, Nguyen, Lien T, De La Cruz-morcillo, Miguel Angel, Blanco-canosa, Juan B, Ramachandran, Sekar, Baillie, George S, Cerione, Richard A, Blanco, Francisco J, Garcia-marcos, Mikel
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.05.2017
• Subjects: Biochemistry; NMR; Nuclear magnetic resonance; Proteins; New York; United States > US; Spain

Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged as critical signalling molecules and...