Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-[kappa]B, Caspase-1/11, ASC, NOX, and NOS Isoforms

• Published in: Inflammation Vol. 40; no. 2; p. 366
• Main Authors: Dolunay, Abdurrahman, Senol, Sefika Pinar, Temiz-resitoglu, Meryem, Guden, Demet Sinem, Sari, Ayse Nihal, Sahan-firat, Seyhan, Tunctan, Bahar
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.04.2017

The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), an intracellular signaling molecule that senses many environmental- and pathogen/host-derived factors, has been implicated in the pathogenesis of several diseases associated with inflammation. It has been suggested that NLRP3 i...