Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-[kappa]B and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells

• Published in: Neurochemical research Vol. 42; no. 2; p. 667
• Main Authors: Zhao, Dong, Kwon, Seung-hwan, Chun, Yoon Sun, Gu, Ming-yao, Yang, Hyun Ok
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.02.2017

Microglia play a critical role in controlling the homeostasis of the brain, but over-activated microglia secrete pro-inflammatory mediators and cytokines, which induce neuronal cell death. Fucoxanthin (Fx), a marine carotenoid, has demonstrated a variety of beneficial health effects. Despite accumul...