Inflammatory landscape of human brain tumors reveals an NF[kappa]B dependent cytokine pathway associated with mesenchymal glioblastoma

• Published in: Cancer letters Vol. 390; p. 176
• Main Authors: Zanotto-Filho, Alfeu, Gonçalves, Rosângela Mayer, Klafke, Karina, de Souza, Priscila Oliveira, Dillenburg, Fabiane Cristine, Carro, Luigi, Gelain, Daniel Pens, Moreira, José Cláudio Fonseca
• Format: Journal Article
• Language: English
• Published: Clare Elsevier Limited 01.04.2017
• Subjects: Angiogenesis; Brain cancer; Cancer; Cancer therapies; Cytokines; Gene expression; Kinases; Studies; Tumor necrosis factor-TNF; Tumors

The tumor microenvironment is being increasingly recognized as a key factor in cancer aggressiveness. In this study, we characterized the inflammatory gene signatures altered in glioma cell lines and tumor specimens of differing histological and molecular subtypes. The results showed that glioblasto...