DLC1 suppresses NF-[kappa]B activity in prostate cancer cells due to its stabilizing effect on adherens junctions

• Published in: SpringerPlus Vol. 3; no. 1; p. 1
• Main Authors: Tripathi, Veenu, Popescu, Nicholas C, Zimonjic, Drazen B
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer Nature B.V 01.01.2014

DLC1 (Deleted in Liver Cancer 1) gene encodes a RhoGTPase-activating protein (RhoGAP), which exerts most of its tumor suppressor functions through suppression of small Rho GTPases proteins RhoA, RhoB, RhoC and to some degree Cdc42, but not Rac. RhoGTPases are implicated in NF-[kappa]B activation in...