Minocycline attenuates bone cancer pain in rats by inhibiting NF-[kappa]B in spinal astrocytes

Aim:To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on bone cancer pain (BCP) in rats.Methods:A rat model of BCP was established by inoculating Walker 256 mammary carcinoma cells into tibial medullary canal. Two weeks later, the rats were injected with minocycline...

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Bibliographic Details
Published inActa pharmacologica Sinica Vol. 37; no. 6; p. 753
Main Authors Song, Zhen-peng, Xiong, Bing-rui, Guan, Xue-hai, Cao, Fei, Manyande, Anne, Zhou, Ya-qun, Zheng, Hua, Tian, Yu-ke
Format Journal Article
LanguageEnglish
Published Shanghai Nature Publishing Group 01.06.2016
Subjects
Bone cancer
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