Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in [beta]-adrenergic signaling and enhances apoptosis

• Published in: Cell death & disease Vol. 6; p. e1754
• Main Authors: Roca-alonso, L, Castellano, L, Mills, A, Dabrowska, A F, Sikkel, M B, Pellegrino, L, Jacob, J, Frampton, A E, Krell, J, Coombes, R C, Harding, S E, Lyon, A R, Stebbing, J
• Format: Journal Article
• Language: English
• Published: London Springer Nature B.V 01.05.2015

The use of anthracyclines such as doxorubicin (DOX) has improved outcome in cancer patients, yet associated risks of cardiomyopathy have limited their clinical application. DOX-associated cardiotoxicity is frequently irreversible and typically progresses to heart failure (HF) but our understanding o...