Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-[alpha] in Primary Cultures of Adult Rat Hepatocytes

• Published in: Biological & pharmaceutical bulletin Vol. 39; no. 4; p. 570
• Main Authors: Naito, Kota, Moteki, Hajime, Kimura, Mitsutoshi, Natsume, Hideshi, Ogihara, Masahiko
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Science and Technology Agency 01.04.2016

The mechanism of serotonin 5-HT2 receptor subtype-stimulated DNA synthesis and proliferation was investigated in primary cultures of adult rat hepatocytes to elucidate the intracellular signal transduction pathways. DNA synthesis and proliferation were detected in hepatocyte parenchymal cells grown...