Systematic biochemical analysis of somatic missense mutations in DNA polymerase [beta] found in prostate cancer reveal alteration of enzymatic function

• Published in: Human mutation Vol. 32; no. 4; p. 415
• Main Authors: An, Chang Long, Chen, Desheng, Makridakis, Nick M
• Format: Journal Article
• Language: English
• Published: Hoboken Hindawi Limited 01.04.2011

DNA polymerase [beta] is essential for short-patch base excision repair. We have previously identified 20 somatic pol [beta] mutations in prostate tumors, many of them missense. In the current article we describe the effect of all of these somatic missense pol [beta] mutations (p.K27N, p.E123K, p.E2...