Structural Analysis of Crystalline R(+)-[alpha]-Lipoic Acid-[alpha]-cyclodextrin Complex Based on Microscopic and Spectroscopic Studies

• Published in: International journal of molecular sciences Vol. 16; no. 10; p. 24614
• Main Authors: Ikuta, Naoko, Endo, Takatsugu, Hosomi, Shota, Setou, Keita, Tanaka, Shiori, Ogawa, Noriko, Yamamoto, Hiromitsu, Mizukami, Tomoyuki, Arai, Shoji, Okuno, Masayuki, Takahashi, Kenji, Terao, Keiji, Matsugo, Seiichi
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2015
• Subjects: Acids; Crystallization; Fourier transforms; Glucose; Spectrum analysis

R(+)-α-lipoic acid (RALA) is a naturally-occurring substance, and its protein-bound form plays significant role in the energy metabolism in the mitochondria. RALA is vulnerable to a variety of physical stimuli, including heat and UV light, which prompted us to study the stability of its complexes wi...