Sorafenib Action in Hepatitis B Virus X-Activated Oncogenic Androgen Pathway in Liver Through SHP-1

• Published in: JNCI : Journal of the National Cancer Institute Vol. 107; no. 10; p. 1
• Main Authors: Wang, Sheng-Han, Yeh, Shiou-Hwei, Shiau, Chung-Wai, Chen, Kuen-Feng, Lin, Wei-Hsiang, Tsai, Ting-Fen, Teng, Yuan-Chi, Chen, Ding-Shinn, Chen, Pei-Jer
• Format: Journal Article
• Language: English
• Published: Oxford Oxford Publishing Limited (England) 01.10.2015
• Subjects: Androgens; Hepatitis; Hepatitis B; Liver; Prescription drugs; Rodents; Tissues

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) shows a higher incidence in men, mainly because of hepatitis B X (HBx)-mediated enhancement of androgen receptor (AR) activity. We aimed to examine this pathway in hepatocarcinogenesis and to identify drug(s) specifically blocking this c...