Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

• Published in: JNCI : Journal of the National Cancer Institute Vol. 107; no. 10; p. 1
• Main Authors: Hong, JongWook, Tobin, Nicholas P, Rundqvist, Helene, Li, Tian, Lavergne, Marion, García-Ibáñez, Yaiza, Qin, Hanyu, Paulsson, Janna, Zeitelhofer, Manuel, Adzemovic, Milena Z, Nilsson, Ingrid, Roswall, Pernilla, Hartman, Johan, Johnson, Randall S, Östman, Arne, Bergh, Jonas, Poljakovic, Mirjana, Genové, Guillem
• Format: Journal Article
• Language: English
• Published: Oxford Oxford Publishing Limited (England) 01.10.2015
• Subjects: Biomarkers; Cells; Gene expression; Genetics; Rodents; Tumors

Pericytes are members of the tumor stroma; however, little is known about their origin, function, or interaction with other tumor components. Emerging evidence suggest that pericytes may regulate leukocyte transmigration. Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with powerf...