Epo-induced erythroid maturation is dependent on Plc[gamma]1 signaling

• Published in: Cell death and differentiation Vol. 22; no. 6; p. 974
• Main Authors: Schnöder, T M, Arreba-tutusaus, P, Griehl, I, Bullinger, L, Buschbeck, M, Lane, S W, Döhner, K, Plass, C, Lipka, D B, Heidel, F H, Fischer, T
• Format: Journal Article
• Language: English
• Published: Rome Nature Publishing Group 01.06.2015

Erythropoiesis is a tightly regulated process. Development of red blood cells occurs through differentiation of hematopoietic stem cells (HSCs) into more committed progenitors and finally into erythrocytes. Binding of erythropoietin (Epo) to its receptor (EpoR) is required for erythropoiesis as it p...