NNC 55-0396, a T-type Ca^sup 2+^ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1[alpha] signal transduction

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 93; no. 5; p. 499
• Main Authors: Kim, Ki Hyun, Kim, Dongyoung, Park, Ju Yeol, Jung, Hye Jin, Cho, Yong-hee, Kim, Hyoung Kyu, Han, Jin, Choi, Kang-yell, Kwon, Ho Jeong
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.05.2015

Mitochondrial respiration is required for hypoxia-inducible factor (HIF)-1[alpha] stabilization, which is important for tumor cell survival, proliferation, and angiogenesis. Herein, small molecules that inhibit HIF-1[alpha] protein stability by targeting mitochondrial energy production were screened...