Hypoxia-Inducible Factor-1 Stimulates Postnatal Lung Development but Does Not Prevent O^sub 2^-Induced Alveolar Injury

• Published in: American journal of respiratory cell and molecular biology Vol. 52; no. 4; p. 448
• Main Authors: Tibboel, Jeroen, Groenman, Freek A, Selvaratnam, Johanna, Wang, Jinxia, Tseu, Irene, Huang, Zhen, Caniggia, Isabella, Luo, Daochun, Tuyl, Minke van, Ackerley, Cameron, de Jongste, Johan C, Tibboel, Dick, Post, Martin
• Format: Journal Article
• Language: English
• Published: New York American Thoracic Society 01.04.2015
• Subjects: Hyperoxia; Hypoxia; Lungs; Proteins; Pulmonary fibrosis; Rodents; Surfactants; Transgenic animals; Vascular endothelial growth factor

This study investigated whether hypoxia-inducible factor (HIF)-1 influences postnatal vascularization and alveologenesis in mice and whether stable (constitutive-active) HIF could prevent hyperoxia-induced lung injury. We assessed postnatal vessel and alveolar formation in transgenic mice, expressin...