The 1.65Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition
The fibroblast growth factor receptor (FGFR) family are expressed widely in normal tissues and play a role in tissue repair, inflammation, angiogenesis and development. However, aberrant signalling through this family can lead to cellular proliferation, evasion of apoptosis and induction of angiogen...
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Published in | Acta crystallographica. Section D, Biological crystallography. Vol. 71; no. 3; p. 525 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Chester
Wiley Subscription Services, Inc
01.03.2015
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Online Access | Get full text |
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