The 1.65Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition

• Published in: Acta crystallographica. Section D, Biological crystallography. Vol. 71; no. 3; p. 525
• Main Authors: Yosaatmadja, Yuliana, Patterson, Adam Vorn, Smaill, Jeff Bruce, Squire, Christopher John
• Format: Journal Article
• Language: English
• Published: Chester Wiley Subscription Services, Inc 01.03.2015

The fibroblast growth factor receptor (FGFR) family are expressed widely in normal tissues and play a role in tissue repair, inflammation, angiogenesis and development. However, aberrant signalling through this family can lead to cellular proliferation, evasion of apoptosis and induction of angiogen...