Increased expression of p21^sup WAF1/CIP1^ in kidney proximal tubules mediates fibrosis

• Published in: American journal of physiology. Renal physiology Vol. 308; no. 2; p. F122
• Main Authors: Megyesi, Judit, Tarcsafalvi, Adel, Li, Shenyang, Hodeify, Rawad, Seng, Nang San Hti Lar, Portilla, Didier, Price, Peter M
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 15.01.2015
• Subjects: Cell culture; Gene expression; Kidney diseases; Mortality; Physiology; Tissues

Tissue fibrosis is a major cause of death in developed countries. It commonly occurs after either acute or chronic injury and affects diverse organs, including the heart, liver, lung, and kidney. Using the renal ablation model of chronic kidney disease, we previously found that the development of pr...