Impaired NLRP3 inflammasome activity during fetal development regulates IL-1[beta] production in human monocytes

• Published in: European journal of immunology Vol. 45; no. 1; p. 238
• Main Authors: Sharma, Ashish A, Jen, Roger, Kan, Bernard, Sharma, Abhinav, Marchant, Elizabeth, Tang, Anthony, Gadawski, Izabelle, Senger, Christof, Skoll, Amanda, Turvey, Stuart E, Sly, Laura M, Cote, Hélène CF, Lavoie, Pascal M
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.01.2015

Interleukin-1[beta] (IL-1[beta]) production is impaired in cord blood monocytes. However, the mechanism underlying this developmental attenuation remains unclear. Here, we analyzed the extent of variability within the Toll-like receptor (TLR)/NLRP3 inflammasome pathways in human neonates. We show th...