TBX3, a downstream target of TGF-[beta]1, inhibits mesangial cell apoptosis

• Published in: Experimental cell research Vol. 328; no. 2; p. 340
• Main Authors: Wensing, Lislaine A, Campos, Alexandre H
• Format: Journal Article
• Language: English
• Published: New York Elsevier BV 01.11.2014
• Subjects: Apoptosis; Gene expression; Kidney diseases; Proteins; Signal transduction

Chronic kidney disease (CKD) is an increasingly common condition characterized by progressive loss of functional nephrons leading to renal failure. TGF-[beta]1-induced mesangial cell (MC) phenotype alterations have been linked to the genesis of CKD. Here we show that TGF-[beta]1 regulates TBX3 gene...