iPLA^sub 2^[beta] Knockout Mouse, a Genetic Model for Progressive Human Motor Disorders, Develops Age-Related Neuropathology

• Published in: Neurochemical research Vol. 39; no. 8; p. 1522
• Main Authors: Blanchard, Helene, Taha, Ameer Y, Cheon, Yewon, Kim, Hyung-wook, Turk, John, Rapoport, Stanley I
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.08.2014

Calcium-independent phospholipase A^sub 2^ group VIa (iPLA^sub 2^[beta]) preferentially releases docosahexaenoic acid (DHA) from the sn-2 position of phospholipids. Mutations of its gene, PLA2G6, are found in patients with several progressive motor disorders, including Parkinson disease. At 4 months...