Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic Effects e2923

• Published in: PLoS neglected tropical diseases Vol. 8; no. 6
• Main Authors: Buro, Christin, Beckmann, Svenja, Oliveira, Katia C, Dissous, Colette, Cailliau, Katia, Marhöfer, Richard J, Selzer, Paul M, Verjovski-Almeida, Sergio, Grevelding, Christoph G
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.06.2014
• Subjects: Cancer therapies; Disease; Eggs; Experiments; Females; Gene expression; Kinases; Parasites; Proteins; Studies; Tropical diseases; Vaccines

Background Schistosome parasites cause schistosomiasis, one of the most important infectious diseases worldwide. For decades Praziquantel (PZQ) is the only drug widely used for controlling schistosomiasis. The absence of a vaccine and fear of PZQ resistance have motivated the search for alternatives...