Infiltrating cellular pattern in kidney graft biopsies translates into forkhead box protein 3 up-regulation and p16INK4[alpha] senescence protein down-regulation in patients treated with belatacept compared to cyclosporin A

• Published in: Clinical and experimental immunology Vol. 167; no. 2; p. 330
• Main Authors: Furuzawa-Carballeda, J, Lima, G, Alberu, J, Palafox, D, Uribe-Uribe, N, Morales-Buenrostro, L E, Reyes Acevedo, R, Mondragon, G, Chevaile, A, Llorente, L
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2012
• Subjects: Biopsy; Proteins; Senescence; Transplants & implants

Summary Renal allograft survival is related directly to cell senescence. In the transplantation scenario many cellular events - participating as immunological and non-immunological factors - could contribute to accelerate this biological process, responsible for the ultimate fate of the graft. Mecha...