Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase II[alpha] Activity Through ATP-Competitive Inhibition

• Published in: Marine drugs Vol. 9; no. 11; p. 2397
• Main Authors: Ponder, Jessica, Yoo, Byong Hoon, Abraham, Adedoyin D, Li, Qun, Ashley, Amanda K, Amerin, Courtney L, Zhou, Qiong, Reid, Brian G, Reigan, Philip, Hromas, Robert, Nickoloff, Jac A, LaBarbera, Daniel V
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2011

Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphim...