An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of Signaling e1004341

• Published in: PLoS genetics Vol. 10; no. 5
• Main Authors: Haag, Andrea, Gutierrez, Peter, Bühler, Alessandra, Walser, Michael, Yang, Qiutan, Langouët, Maeva, Kradolfer, David, Fröhli, Erika, Herrmann, Christina J, Hajnal, Alex, Escobar-Restrepo, Juan M
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.05.2014
• Subjects: Animals; Epidermal growth factor; Genotype & phenotype; Kinases

The subcellular localization of the epidermal growth factor receptor (EGFR) in polarized epithelial cells profoundly affects the activity of the intracellular signaling pathways activated after EGF ligand binding. Therefore, changes in EGFR localization and signaling are implicated in various human...