Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection e1004134

• Published in: PLoS pathogens Vol. 10; no. 5
• Main Authors: Kedzierski, Lukasz, Linossi, Edmond M, Kolesnik, Tatiana B, Day, E Bridie, Bird, Nicola L, Kile, Benjamin T, Belz, Gabrielle T, Metcalf, Donald, Nicola, Nicos A, Kedzierska, Katherine, Nicholson, Sandra E
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.05.2014
• Subjects: Bone marrow; Chemokines; Cytokines; Flow cytometry; Immune system; Infections; Kinases; Lungs; Lymphocytes; Mortality; Proteins; Scholarships & fellowships; Swine flu; T cell receptors; Viral infections

Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pa...