Results of local treatment of retinoblastoma after polychemotherapy

• Published in: Oftalʼmokhirurgii͡a︡ = Ophthalmosurgery no. 1; p. 79
• Main Authors: Yarovoy, A A, Ushakova, T L, Polyakov, V G, Bulgakova, E S, Krivovyaz, O S, Gorovtsova, O V
• Format: Journal Article
• Language: Russian
• Published: Moscow Ministerstvo Zdravookhraneniya i Social'nogo Razvitiya Rossiyskoy Federatsii FGBU MNTK Mikrokhirurgiya Glaza Imeni Akademika S.N. Fyodorova 01.01.2014
• Subjects: Chemotherapy; Eye diseases; Eyes & eyesight; Ophthalmology; Retina
• ISSN: 0235-4160

Yarovoy et al evaluate the results of the local treatment in cases of insufficient efficacy of retinoblastoma response to chemotherapy. The study included 35 children (43 eyes) with insufficient response to the systemic and local chemotherapy (brachytherapy, cryosurgery, transpupillary diode-laser thermotherapy) which have a local impact on 101 retinoblastoma foci. Bilateral retinoblastoma was observed in 26 children, 16 children were monocular. Eight eyes comprised group A, 12 for group B. 13 for group C and 10 for group D. Forty five tumors were treated using the brachytherapy. In 7 eyes the plaques were relocated successively to irradiate two or three tumors. The transpupillary thermotherapy was performed in 32 tumors, the cryotherapy in 24 foci. The follow-up was from 9 to 66 months. Results indicated the important role of the local methods in the system of organ-saving treatment of patients with retinoblastoma especially in case of exhausted reserves of chemotherapy.