Activation of [beta]-catenin/TCF targets following loss of the tumor suppressor SNF5
The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using co...
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| Published in | Oncogene Vol. 33; no. 7; p. 933 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group
13.02.2014
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| Abstract | The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies [beta]-catenin hyperactivation and that SNF5 is essential for regulating Wnt/[beta]-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control. [PUBLICATION ABSTRACT] |
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| AbstractList | The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies [beta]-catenin hyperactivation and that SNF5 is essential for regulating Wnt/[beta]-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control. [PUBLICATION ABSTRACT] |
| Author | Mora-blanco, E L Roberts, C W M Cho, Y-j Pomeroy, S L Mishina, Y Shao, W Tillman, E J Thom, C S |
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| Copyright | Copyright Nature Publishing Group Feb 13, 2014 |
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| DOI | 10.1038/onc.2013.37 |
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| Title | Activation of [beta]-catenin/TCF targets following loss of the tumor suppressor SNF5 |
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