Short-Chain Fatty Acids Activate AMP-Activated Protein Kinase and Ameliorate Ethanol-Induced Intestinal Barrier Dysfunction in Caco-2 Cell Monolayers1,2

• Published in: The Journal of nutrition Vol. 143; no. 12; p. 1872
• Main Authors: Elamin, Elhaseen E, Masclee, Ad A, Dekker, Jan, Pieters, Harm-Jan, Jonkers, Daisy M
• Format: Journal Article
• Language: English
• Published: Bethesda American Institute of Nutrition 01.12.2013
• Subjects: Cytoskeleton; Ethanol; Experiments; Homeostasis; Kinases; Liver diseases; Metabolites; Oxidative stress; Permeability; Proteins; Small intestine; Stress; Studies

Short-chain fatty acids (SCFAs) have been shown to promote intestinal barrier function, but their protective effects against ethanol-induced intestinal injury and underlying mechanisms remain essentially unknown. The aim of the study was to analyze the influence of SCFAs on ethanol-induced barrier d...