EVALUATION OF A 5-DAY HERSHBERGER ASSAY USING YOUNG MATURE MALE RATS

• Published in: Journal of toxicological sciences Vol. 25; no. 5; p. 403
• Main Authors: SUNAMI, Osamu, KUNIMATSU, Takeshi, YAMADA, Tomoya, YABUSHITA, Setsuko, SUKATA, Tokuo, MIYATA, Kaori, KAMITA, Yusuke, OKUNO, Yasuyoshi, SEKI, Takaki, NAKATSUKA, Iwao, MATSUO, Masatoshi
• Format: Journal Article
• Language: English
• Published: Suita Japan Science and Technology Agency 20.10.2000

A 5-day Hershberger assay using young mature male rats to detect compounds interfering with androgen receptor(AR)-mediated mechanisms was evaluated for ability to identify p, p'-DDE(a weak AR antagonist)and methyltestosterone(MT, an AR agonist). Fenitrothion, an organophosphate pesticide, was a...