Signaling mediated by the NF-[kappa]B sub-units NF-[kappa]B1, NF-[kappa]B2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice

• Published in: Oncogene Vol. 32; no. 50; p. 5563
• Main Authors: Burkitt, M D, Williams, J M, Duckworth, C A, O'hara, A, Hanedi, A, Varro, A, Caamaño, J H, Pritchard, D M
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group 12.12.2013
• Subjects: Bacteria; Cancer; Gastroenterology; Rodents; Signaling

The classical nuclear factor-kappaB (NF-κB) signaling pathway has been shown to be important in a number of models of inflammation-associated cancer. In a mouse model of Helicobacter-induced gastric cancer, impairment of classical NF-κB signaling in the gastric epithelium led to the development of i...