Carbocyclic Analogues of Nucleosides from bis-(Hydroxymethyl)-cyclopentane

Six new carbocyclic nucleosides were prepared by constructing a purine base (in compounds 9--11) or pyrimidine base (in 6--8) on the amino groups of (±)-(1β,2α,4β)-4-amino-1,2-cyclopentanedimethanol (4) and (±)-(1β,3α,4β)-4-amino-1,3-cyclopentanedimethanol (5), and their activities against a variety...

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Published inChemical & pharmaceutical bulletin Vol. 51; no. 9; p. 1060
Main Authors Manuel Blanco, José, Caamaño, Olga, Fernández, Franco, Enrique Rodríguez-Borges, José, Balzarini, Jan, de Clercq, Erik
Format Journal Article
LanguageEnglish
Published Tokyo Japan Science and Technology Agency 01.09.2003
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Abstract Six new carbocyclic nucleosides were prepared by constructing a purine base (in compounds 9--11) or pyrimidine base (in 6--8) on the amino groups of (±)-(1β,2α,4β)-4-amino-1,2-cyclopentanedimethanol (4) and (±)-(1β,3α,4β)-4-amino-1,3-cyclopentanedimethanol (5), and their activities against a variety of viruses and tumour cell lines were determined.
AbstractList Six new carbocyclic nucleosides were prepared by constructing a purine base (in compounds 9--11) or pyrimidine base (in 6--8) on the amino groups of (±)-(1β,2α,4β)-4-amino-1,2-cyclopentanedimethanol (4) and (±)-(1β,3α,4β)-4-amino-1,3-cyclopentanedimethanol (5), and their activities against a variety of viruses and tumour cell lines were determined.
Author Caamaño, Olga
Enrique Rodríguez-Borges, José
Manuel Blanco, José
Fernández, Franco
de Clercq, Erik
Balzarini, Jan
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Snippet Six new carbocyclic nucleosides were prepared by constructing a purine base (in compounds 9--11) or pyrimidine base (in 6--8) on the amino groups of...
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