TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis e1003646

• Published in: PLoS pathogens Vol. 9; no. 10
• Main Authors: Park, Young-Jun, Yoon, Sung-Jin, Suh, Hyun-Woo, Kim, Dong Oh, Park, Jeong-Ran, Jung, Haiyoung, Kim, Tae-Don, Yoon, Suk Ran, Min, Jeong-Ki, Na, Hee-Jun, Lee, Seon-Jin, Lee, Hee Gu, Lee, Young Ho, Lee, Hee-Bong, Choi, Inpyo
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.10.2013
• Subjects: Apoptosis; Cell growth; E coli; Experiments; Nitric oxide; Proteins; Regulation; Rodents

Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. However, its role in the inflammatory process remains unclear. In this report, we demonstrate that Txnip-/- mice are significantly more susceptible to lipo...