PPAR[gamma] ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis

• Published in: Medical molecular morphology Vol. 46; no. 3; p. 153
• Main Authors: Nozaki, Yusuke, Harada, Kenichi, Sanzen, Takahiro, Nakanuma, Yasuni
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Nature B.V 01.09.2013
• Subjects: Liver cirrhosis; Molecular biology; Pathogenesis; Rodents

Primary biliary cirrhosis (PBC) is characterized by chronic destructive cholangitis, which is associated with the reduced expression of an anti-inflammatory molecule, peroxisome proliferator-activated receptor-γ (PPARγ), in intrahepatic bile ducts. We previously demonstrated the anti-inflammatory ef...