Sequential Waves of Gene Expression in Patients with Clinically Defined Dengue Illnesses Reveal Subtle Disease Phases and Predict Disease Severity e2298

• Published in: PLoS neglected tropical diseases Vol. 7; no. 7
• Main Authors: Sun, Peifang, García, Josefina, Comach, Guillermo, Vahey, Maryanne T, Wang, Zhining, shey, Brett M, Morrison, Amy C, Sierra, Gloria, Bazan, Isabel, Rocha, Claudio, Vilcarromero, Stalin, Blair, Patrick J, Scott, Thomas W, Camacho, Daria E, Ockenhouse, Christian F, Halsey, Eric S, Kochel, Tadeusz J
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.07.2013
• Subjects: Cell cycle; Dengue fever; Disease; Fever; Gene expression; Plasma; Tropical diseases

Background Dengue virus (DENV) infection can range in severity from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Changes in host gene expression, temporally through the progression of DENV infection, especially during the early days, remains poorly...