Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation e2307

• Published in: PLoS neglected tropical diseases Vol. 7; no. 7
• Main Authors: Thivierge, Karine, Cotton, Sophie, Schaefer, Deborah A, Riggs, Michael W, To, Joyce, Lund, Maria E, Robinson, Mark W, Dalton, John P, Donnelly, Sheila M
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.07.2013
• Subjects: Biochemistry; Cytokines; Immune system; Mammals; Medical research; Parasites; Peptides; Tropical diseases; Wound healing

Host defence peptides (HDPs) are expressed throughout the animal and plant kingdoms. They have multifunctional roles in the defence against infectious agents of mammals, possessing both bactericidal and immune-modulatory activities. We have identified a novel family of molecules secreted by helminth...