Placental Growth Factor (PlGF)-Specific Uptake in Tumor Microenvironment of ^sup 89^Zr-Labeled PlGF Antibody RO5323441

• Published in: The Journal of nuclear medicine (1978) Vol. 54; no. 6; p. 929
• Main Authors: Munnink, Thijs H Oude, Tamas, Karin R, Lub-de Hooge, Marjolijn N, Vedelaar, Silke R, Timmer-Bosscha, Hetty, Walenkamp, Annemiek ME, Weidner, K Michael, Herting, Frank, Tessier, Jean, de Vries, Elisabeth GE
• Format: Journal Article
• Language: English
• Published: New York Society of Nuclear Medicine 01.06.2013
• Subjects: Cell growth; Microscopy; Monoclonal antibodies; Rodents; Skin & tissue grafts; Tumors

Placental growth factor (PlGF) is a member of the proangiogenic vascular endothelial growth factor family, which is upregulated in many tumors. RO5323441, a humanized monoclonal antibody against PlGF, showed antitumor activity in human tumor xenografts. We therefore aimed to radiolabel RO5323441 and...