Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-[beta]1 therapies in inducible nitric oxide synthase-deficient mice

• Published in: BJU international Vol. 109; no. 4; p. 586
• Main Authors: Ferrini, Monica G, Moon, Joanne, Rivera, Steve, Rajfer, Jacob, Gonzalez-Cadavid, Nestor F
• Format: Journal Article
• Language: English
• Published: Edgecliff Wiley Subscription Services, Inc 01.02.2012
• Subjects: Antioxidants; Apoptosis; Collagen; Nitric oxide; Oxidative stress; Rodents; Smooth muscle

Study Type - Aetiology (case control) Level of Evidenceâ[euro]1b What's known on the subject? and What does the study add? The development of penile fibrosis in diabetes is associated with an increase in oxidative stress and the key pro-fibrotic factor. TGF[beta]1 within the corpora. As a conse...