Parasites FeS Up: Iron-Sulfur Cluster Biogenesis in Eukaryotic Pathogens e1003227
Recently, it was demonstrated that the product of the isoprenoid biosynthesis pathway, isopentenyl pyrophosphate (IPP), could sustain growth of malaria parasites when the apicoplast was ablated by antibiotic treatment, suggesting that export of this metabolite to the cytosol is the only essential fu...
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| Published in | PLoS pathogens Vol. 9; no. 4 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
San Francisco
Public Library of Science
01.04.2013
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| Abstract | Recently, it was demonstrated that the product of the isoprenoid biosynthesis pathway, isopentenyl pyrophosphate (IPP), could sustain growth of malaria parasites when the apicoplast was ablated by antibiotic treatment, suggesting that export of this metabolite to the cytosol is the only essential function of the apicoplast in the blood stages of the parasite lifecycle [9]. Since the SUF pathway supplies FeS clusters to two enzymes of the pathway that produces IPP, this finding also strongly suggests that FeS cluster biogenesis in the apicoplast is essential for parasite viability. [...]the enzymes of the SUF pathway are attractive candidates for development of new drug targets because of their essentiality as well as their prokaryotic origin, which makes them significantly different from any enzymes found in the host cell. |
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| AbstractList | Recently, it was demonstrated that the product of the isoprenoid biosynthesis pathway, isopentenyl pyrophosphate (IPP), could sustain growth of malaria parasites when the apicoplast was ablated by antibiotic treatment, suggesting that export of this metabolite to the cytosol is the only essential function of the apicoplast in the blood stages of the parasite lifecycle [9]. Since the SUF pathway supplies FeS clusters to two enzymes of the pathway that produces IPP, this finding also strongly suggests that FeS cluster biogenesis in the apicoplast is essential for parasite viability. [...]the enzymes of the SUF pathway are attractive candidates for development of new drug targets because of their essentiality as well as their prokaryotic origin, which makes them significantly different from any enzymes found in the host cell. |
| Author | Gisselberg, Jolyn E Prigge, Sean T Dellibovi-Ragheb, Teegan A |
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| Copyright | 2013 Dellibovi-Ragheb et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Dellibovi-Ragheb TA, Gisselberg JE, Prigge ST (2013) Parasites FeS Up: Iron-Sulfur Cluster Biogenesis in Eukaryotic Pathogens. PLoS Pathog 9(4): e1003227. doi:10.1371/journal.ppat.1003227 |
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| DOI | 10.1371/journal.ppat.1003227 |
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