Consensus-Phenotype Integration of Transcriptomic and Metabolomic Data Implies a Role for Metabolism in the Chemosensitivity of Tumour Cells e1001113

• Published in: PLoS computational biology Vol. 7; no. 3
• Main Authors: Cavill, Rachel, Kamburov, Atanas, Ellis, James K, Athersuch, Toby J, Blagrove, Marcus SC, Herwig, Ralf, Ebbels, Timothy MD, Keun, Hector C
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.03.2011
• Subjects: Cancer therapies; Chemotherapy; Experiments; Genotype & phenotype; Metabolism; Metabolites; Studies

Using transcriptomic and metabolomic measurements from the NCI60 cell line panel, together with a novel approach to integration of molecular profile data, we show that the biochemical pathways associated with tumour cell chemosensitivity to platinum-based drugs are highly coincident, i.e. they descr...