Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression e1000930

• Published in: PLoS pathogens Vol. 6; no. 6
• Main Authors: Soucy-Faulkner, Anton, Mukawera, Espérance, Fink, Karin, Martel, Alexis, Jouan, Loubna, Nzengue, Yves, Lamarre, Daniel, Velde, Christine Vande, Grandvaux, Nathalie
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.06.2010
• Subjects: Apoptosis; Experiments; Immune response; Immune system; Kinases; Medical research; Mitochondria; Nucleic acids; Proteins; Viruses

The innate immune response is essential to the host defense against viruses, through restriction of virus replication and coordination of the adaptive immune response. Induction of antiviral genes is a tightly regulated process initiated mainly through sensing of invading virus nucleic acids in the...