CD8+ T Cells Restrict Yersinia pseudotuberculosis Infection: Bypass of Anti-Phagocytosis by Targeting Antigen-Presenting Cells e1000573

• Published in: PLoS pathogens Vol. 5; no. 9
• Main Authors: Bergman, Molly A, Loomis, Wendy P, Mecsas, Joan, Starnbach, Michael N, Isberg, Ralph R
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.09.2009
• Subjects: Bacteria; Disease; Experiments; Food contamination & poisoning; Infections; Lymphocytes; Plague; Proteins; Statistical analysis

All Yersinia species target and bind to phagocytic cells, but uptake and destruction of bacteria are prevented by injection of anti-phagocytic Yop proteins into the host cell. Here we provide evidence that CD8+ T cells, which canonically eliminate intracellular pathogens, are important for restricti...