Nucleocapsid Promotes Localization of HIV-1 Gag to Uropods That Participate in Virological Synapses between T Cells e1001167

• Published in: PLoS pathogens Vol. 6; no. 10
• Main Authors: Llewellyn, G Nicholas, Hogue, Ian B, Grover, Jonathan R, Ono, Akira
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.10.2010
• Subjects: Acquired immune deficiency syndrome; Acquisitions & mergers; AIDS; Amino acids; Biomedical research; Colleges & universities; Lymphocytes; Plasma; Training

T cells adopt a polarized morphology in lymphoid organs, where cell-to-cell transmission of HIV-1 is likely frequent. However, despite the importance of understanding virus spread in vivo, little is known about the HIV-1 life cycle, particularly its late phase, in polarized T cells. Polarized T cell...