Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa e1000704

• Published in: PLoS pathogens Vol. 5; no. 12
• Main Authors: Price, Christopher T, Al-Khodor, Souhaila, Al-Quadan, Tasneem, Santic, Marina, Habyarimana, Fabien, Kalia, Awdhesh, Kwaik, Yousef Abu
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.12.2009
• Subjects: Aquatic environment; Bacteriology; Exploitation; Legionnaire's disease; Legionnaires' disease; Microbiology; Proteins; Translocation

The ability of Legionella pneumophila to proliferate within various protozoa in the aquatic environment and in macrophages indicates a remarkable evolution and microbial exploitation of evolutionarily conserved eukaryotic processes. Ankyrin B (AnkB) of L. pneumophila is a non-canonical F-box-contain...