Varicellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP e1000080

• Published in: PLoS pathogens Vol. 4; no. 5
• Main Authors: Koppers-Lalic, Danijela, Verweij, Marieke C, Lipinska, Andrea D, Wang, Ying, Quinten, Edwin, Reits, Eric A, Koch, Joachim, Loch, Sandra, Rezende, Marisa Marcondes, Daus, Franz, Bienkowska-Szewczyk, Krystyna, Osterrieder, Nikolaus, Mettenleiter, Thomas C, Heemskerk, Mirjam HM, Tampé, Robert, Neefjes, Jacques J, Chowdhury, Shafiqul I, Ressing, Maaike E, Rijsewijk, Frans AM, Wiertz, J HJ
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.05.2008
• Subjects: Cytotoxicity; Experiments; Genes; Lymphocytes; Peptides; Proteins; Viral infections; Viruses

Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell. The transporter associated with antigen processing (T...