Potential Drug Development Candidates for Human Soil-Transmitted Helminthiases e1138

• Published in: PLoS neglected tropical diseases Vol. 5; no. 6
• Main Authors: Olliaro, Piero, Seiler, Jürg, Kuesel, Annette, Horton, John, Clark, Jeffrey N, Don, Robert, Keiser, Jennifer
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.06.2011
• Subjects: Candidates; Chemotherapy; Drug dosages; Infections; Medical research; Pharmaceutical industry; Tropical diseases; Veterinary medicine

Background Few drugs are available for soil-transmitted helminthiasis (STH); the benzimidazoles albendazole and mebendazole are the only drugs being used for preventive chemotherapy as they can be given in one single dose with no weight adjustment. While generally safe and effective in reducing inte...